FT- SERS Study of Adriamycin - DNA Intraction
نویسنده
چکیده مقاله:
FT-SERS (Fourier Transform Surface Enhanced Raman Scattering) of adriamycin and its complex with DNA is reported. It is shown that in agreement with previous Raman studies the interaction of adriamycin with DNA takes place through an intercalation mechanism. The presence of a new band at 731 cm-1 suggests that ring D of adriamycin is not involved in the intercalation process.
منابع مشابه
ft- sers study of adriamycin - dna intraction
ft-sers (fourier transform surface enhanced raman scattering) of adriamycin and its complex with dna is reported. it is shown that in agreement with previous raman studies the interaction of adriamycin with dna takes place through an intercalation mechanism. the presence of a new band at 731 cm-1 suggests that ring d of adriamycin is not involved in the intercalation process.
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isotherms of the binding of the anthracyciine antibiotic, adriamycin (adriblastin), to dna histone complexes was studied by means of spectroscopic analysis. the results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with dna, (b) binding of the drug to dna did not change the binding affinity of histone to dna and, (c) in the explored binding range of r
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عنوان ژورنال
دوره 22 شماره 1
صفحات 9- 11
تاریخ انتشار 2003-04-01
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